Health

Claudia Cowan

San Francisco, CA

48

comments

Tracking H1N1 Mutations

November 11, 2009 - 2:43 PM | by: Claudia Cowan

Genetically, the H1N1 virus hasn't changed much since it first appeared last April, but experience has shown influenza viruses tend to evolve -- sometimes with catastrophic results.

In 1918, a relatively mild strain of Spanish flu suddenly became much more virulent, killing millions of people in a global pandemic.

Making sure that doesn't happen with H1N1 is the goal of Dr. Charles Chu, Director of the Viral Detection and Discovery Center in San Francisco.

He and his his team are monitoring H1N1 flu samples from around the globe looking for changes in the virus that might impact the effectiveness of the vaccine or have other medical implications.

His lab is filled with freezers full of flu specimens and machinery that compares DNA from those samples with the genetic makeup of thousands of other known viruses. Within hours his team knows whether the specimen is something public health officials need to be alerted to. If they can detect new outbreaks in their earliest stages, it could save thousands of lives.

Flu bugs morph and mutate all the time, which is why there's a new seasonal flu vaccine every year.

But what worries researchers are major mutations which essentially create a new virus that can be resistant to drugs, more virulent, and potentially much more dangerous.

Magpiezoe

Now I'm comfused. So why get the H1N1 flu shot, if the virus is mutating? The shot would be worthless, if it mutates into a supervirus.

November 12, 2009 at 11:01 AM
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Phil

so whats the story here? The flu may change and get worse? seems like a non-story to me until it actually happens...

November 12, 2009 at 10:42 AM
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WAS A NON- BELIEVER

So at first I thought this was way over hyped.... Then we started getting patients into our ICU that have had no medical issues EVER and are knocking on deaths door. They're not coming in with H1N1, they are coming in with pneumonia and are in ARDS very quickly. IT IS SCARY! Take precautions and don't be stupid. If you do get sick... don't lay around to get better. Get up and move so you don't get pneumonia.

November 12, 2009 at 10:07 AM
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Ryan

Please people do some real research before making false claims and spreading rumors. There is NO squalene in the H1N1 vaccine. Only the multi-dose vials of the vaccine contain Thermisol (containing small amounts of mercury), and there have been no REPUTABLE medical studies linking Thermisol to anything negative. The H1N1 vaccine is produced in exactly the same way as the seasonal flu vaccine, which has been used and tested for years. It would have been rolled into the seasonal vaccine if it was discovered a few months earlier. Conspiracy theories or health of mother and baby...easy choice.

November 12, 2009 at 10:02 AM
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www.h1n1virusfacts.com

Getting the facts about this virus is what will keep you,your family and your friends safe and healthy during this Flu season. Prevention,symptoms and treatment updates.

November 12, 2009 at 9:57 AM
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andy

its the puemonic plague in the ukraine and serbia and headed our way.no vaccine is gonna help you.

November 12, 2009 at 8:20 AM
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Jen

I was admitted to the hospital with the N1H1 virus and I am now told that I am fortunate to have survived. I am 35 weeks pregnant and this virus took a huge toll on my body as I am still trying to get over it, my breathing is still compromised and I am now on an inhaler. I encourage any pregnant woman to get the N1H1 vaccine, the fear that I went through do to this is not worth my childs life or my own.

November 12, 2009 at 8:13 AM
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jamn2dblues

I have it and it is misery! Tired and weak, when all said and done. No energy to eat all you can do is sleep. God Bless Strength to us in our late 40's who get it... and i hope your work is nicer than mine. When i finally get back to work if i still have a job. inconvenience was the word used to me, like this has been a spa med vaca for me!

November 12, 2009 at 7:49 AM
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Fozzie

I'm a teacher and I would estimate that about 75% of my students have already caught the flu. It has almost run its course in my community.

November 12, 2009 at 2:41 AM
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Bob

It's no big deal unless you're the sickly type. It's just the flu. I live down here in Mexico and it seems like 80% of my American friend's kids (and some adults, including myself) have caught it. You catch the flu, you get over it and move on. You're likely wasting your time worrying about the vacine unless your a "high risk" person. I would be more concerned about taking some bad vacine and getting sick from that then catching the flu.

November 12, 2009 at 1:30 AM
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TOM

"Genetically, the H1N1 virus hasn't changed much since it first appeared last April"??? UKRAINE-UKRAINE-UKRAINE!!!

November 12, 2009 at 12:30 AM
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Marc

The big worry about H1N1 and all Flu is not so much the Virus,but the complications. People died from Bacterial Pneumonia in the past. There is a Vaccine for 23 strains of Pneumo causing bugs. My Doc recommended that we get that and not the Flu shots. If you get the H1N1 shot, you have to get the regular Flu shot too, because you will be more susceptible if you don't. If you have had the Pneumo vaccine in the last 10 years, Or 5 if over 50, you should still be covered. I would have had to take all 3, and my Doc felt that the triple dose of Mercury and a Formaldehyde derivative (preservatives) was not a good risk for the 50% reduction in Flu cases documented so far. He has Tamiflu if I need it.

November 12, 2009 at 12:25 AM
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Laura

Why is it taking so long to get the sequence information for the H1N1 in Ukraine? Samples were sent to London and confirmed H1N1, but no information has been released about mutations. Reports are that the cases there are spreading more rapidly and are more deadly. Nov 3 until Nov 11 - that's nine days. It sounds like we have the technology to determine definitively within hours if mutations are present. Yet after nine days we have no answer. I think the world needs to know.

November 11, 2009 at 11:19 PM
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BorderPatrol

There have been an incresing number of Tamiflu resistant cases around the World. More worisome is the situation in the Ukraine which is reminiscent of the early days of the Spanish Flu. While we have many advances in medical science, the size and scope of a 'Spanish Flu' type outbreak would overwhelm the medical system overnight, and they know it. After a month how many people are waiting for immunization? Not a promising scenario.

November 11, 2009 at 8:37 PM
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Scott

Overhyped. Sensatonalized. Over the top covereage. I thought that too about H1N1 until I read historical information regarding past pandemcis and how they spread. I say keep looking for those mutations. All you non beleivers google "blue skin pandemic" Young people shouldnt be turning blue and dying from the flu

November 11, 2009 at 6:58 PM
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Someone kick me

Well, on Monday they finally offered flu shots for children that were high risk. Gee, my son came down with H1N1 over the week-end. He has asthma and it has kicked his butt. This is a great example of socialized medicine. The government is telling us who is allowed to get the injection and when. I would rest easier with less governmental involvement,

November 11, 2009 at 6:29 PM
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Edward Jan Klinard

Just reading the last comment in the article pasted below. Sounds like we have that already. Lungs dissolving in the Ukraine. You have to be very careful with electron exchange in breathing in O2 and exhaling CO2 in the presence of a quickly mutating virus like H1N1 and anomalies within the earth's magnetic flux caused by the Kursk anomaly. You scientists are just brilliant and Einstein summed it up more politely, science without religion is lame and religion without science is blind. Sincerely, Brother Silver Hurst, Disciple of Christ and Root of David. Go ahead, analyze all of them. Three wise men followed a starship. My brothers are back. http://cid-ef6ba48532841ac8.skydrive.live.com/browse.aspx/Romans%20Ate%20T%20P?uc=1&isFromRichUpload=1 But what worries researchers are major mutations which essentially create a new virus that can be resistant to drugs, more virulent, and potentially much more dangerous.

November 11, 2009 at 6:12 PM
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tommyt

get the shot. lol

November 11, 2009 at 5:57 PM
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Clyde

Won't if be funny to look back at this H1N1 BS with all the same intelligence we developed after the Y2K fiasco? Yes, several people have died and that is truly unfortunate but what percentage of those individuals were already suffering from other illnesses? What percentage could have survived if they had received quicker medical care? For those with short memories, everyone was saying that on December 31, 1999, possibly everything in the world was going to stop because the computers were going to stop. How many billions of dollars were wasted over that baloney? I feel that this H1N1 garbage is just another thing drummed up to keep everyone running around like Chicken Little.

November 11, 2009 at 5:46 PM
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bob

Seriously this Pharma hype is very disturbing, very unethical and needs to stop.

November 11, 2009 at 5:12 PM
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